"DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRY2, KIAA0232, and FAM72B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "DNA damage response, signal transduction by p53 class mediator" activity versus CRY2 in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRY2 →	-0.783	-0.436	<.001	<.001	3	6
BRCA	KIAA0232 →	-0.664	-0.279	<.001	.001	3	5
BRCA	FAM72B →	+0.732	+0.345	<.001	<.001	3	5
BRCA	PSME2P2 →	+0.955	+0.247	<.001	.003	3	5
LSCC	GBP1 →	+0.510	+0.208	.009	<.001	3	5
GBM	ATP8A1 →	-0.871	-0.246	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030330 vs CRY2 — BRCA

Explore this scatter interactively →