Across TCGA pan-cancer cohorts, RNA activity of the Stabilization of membrane potential pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Stabilization of membrane potential pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and MESO, show the opposite pattern, with higher activity associated with better survival.
BLCA, KIRP, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.
Pathway-activity survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.