Transepithelial chloride transport

Across TCGA patient cohorts, RNA activity of the Transepithelial chloride transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, FUS, and RCOR3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial chloride transport activity versus UPP1 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UPP1 →	+0.611	+0.066	<.001	<.001	3	7
GBM	FUS →	-0.305	-0.076	.001	<.001	3	7
GBM	RCOR3 →	-0.269	-0.080	<.001	<.001	3	7
GBM	GTF2I →	-0.383	-0.062	<.001	<.001	3	7
GBM	HNRNPK →	-0.224	-0.066	<.001	<.001	3	7
GBM	NCF2 →	+0.587	+0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030321 vs UPP1 — HNSC

Explore this scatter interactively →