Negative regulation of cell growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell growth pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, UCHL1, and PALM2AKAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell growth activity versus MAP1A in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAP1A →	+0.666	+0.039	<.001	.002	3	10
UCEC	UCHL1 →	+0.919	+0.042	.001	<.001	3	9
CCRCC	PALM2AKAP2 →	+0.432	+0.027	<.001	<.001	3	9
LSCC	PPM1F →	+0.300	+0.045	<.001	<.001	3	9
LSCC	RSU1 →	+0.355	+0.034	<.001	<.001	3	8
BRCA	SEPTIN11 →	+0.373	+0.027	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030308 vs MAP1A — HNSC

Explore this scatter interactively →