Negative regulation of ossification

Across TCGA patient cohorts, RNA activity of the Negative regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP2, APLNR, and RHOJ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ossification activity versus ESRP2 in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ESRP2 →	-0.485	-0.216	<.001	.004	3	6
UCEC	APLNR →	+0.687	+0.769	.003	<.001	3	5
BRCA	RHOJ →	+0.558	+0.430	<.001	<.001	3	5
BRCA	TWIST2 →	+0.738	+0.485	.009	.003	3	5
CCRCC	VIM →	+0.725	+0.906	<.001	<.001	3	5
HNSC	IGDCC4 →	+0.915	+0.761	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030279 vs ESRP2 — PDAC

Explore this scatter interactively →