Negative regulation of ossification

Across TCGA cell cohorts, RNA activity of the Negative regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF8, CHPF, and PI4KB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAF8 grouped by Negative regulation of ossification-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NDUFAF8 →	-1.146	-1.092	<.001	.001	3	4
SKIN	CHPF →	-0.964	-0.829	.006	<.001	3	4
SKIN	PI4KB →	-0.465	-0.806	.008	.005	3	4
BREAST	GCFC2 →	+0.627	+0.925	.004	.003	3	3
BLOOD_Leukemia	ABTB1 →	-1.171	-0.989	.006	.009	3	3
BLOOD_Leukemia	COA7 →	+0.770	+1.258	.004	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAF8 by Negative regulation of ossification activity — KIDNEY

Explore this box plot interactively →