Negative regulation of ossification

Across TCGA cell cohorts, RNA activity of the Negative regulation of ossification pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGR6, SULT1C2, and MED15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGR6 grouped by Negative regulation of ossification-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LGR6 →	-0.253	-0.077	<.001	<.001	3	5
BREAST	SULT1C2 →	+0.160	+0.060	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MED15 →	-0.253	-0.155	.001	.005	3	4
CNS	SMARCC1 →	-0.197	-0.050	<.001	.008	3	4
KIDNEY	CHMP7 →	+0.219	+0.076	.001	.005	3	4
OVARY	PTPA →	-0.231	-0.106	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGR6 by Negative regulation of ossification activity — LUNG_SCLC

Explore this box plot interactively →