Negative regulation of ossification

Across TCGA cell cohorts, RNA activity of the Negative regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXTL2, ERLEC1, and PCNT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ossification activity versus EXTL2 in LUNG_NSCLC_LUSC (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EXTL2 →	-1.489	-2.202	.004	<.001	3	4
BLOOD_Lymphoma	ERLEC1 →	-1.121	-0.398	.001	.006	3	4
SKIN	PCNT →	-0.600	-0.770	<.001	<.001	3	3
SKIN	TMEM240 →	-0.710	-0.660	.001	.008	3	3
LUNG_NSCLC_LUSC	EID1 →	-1.976	-2.192	<.001	.003	3	3
SKIN	ZNF263 →	-0.565	-0.591	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030279 vs EXTL2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →