Maintenance of gastrointestinal epithelium

Across TCGA patient cohorts, RNA activity of the Maintenance of gastrointestinal epithelium pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFTUD2, CSE1L, and DDX52, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of gastrointestinal epithelium activity versus EFTUD2 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EFTUD2 →	-0.238	-0.066	<.001	<.001	3	7
UCEC	CSE1L →	-0.339	-0.078	<.001	<.001	3	7
BRCA	DDX52 →	-0.382	-0.059	<.001	<.001	3	7
BRCA	RRP1B →	-0.601	-0.071	<.001	<.001	3	6
OV	SDAD1 →	-0.210	-0.032	.002	.004	3	6
BRCA	MCM2_S139 →	-0.376	-0.047	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030277 vs EFTUD2 — BRCA

Explore this scatter interactively →