Maintenance of gastrointestinal epithelium

Across TCGA cell cohorts, RNA activity of the Maintenance of gastrointestinal epithelium pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP7, ATP8B1, and C11orf45, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP7 grouped by Maintenance of gastrointestinal epithelium-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	USP7 →	+0.331	+0.227	<.001	.001	3	5
BREAST	ATP8B1 →	-0.104	-0.146	.001	.009	3	4
BONE	C11orf45 →	+0.392	+0.530	.009	<.001	3	4
BONE	BTNL2 →	+0.176	+0.359	.005	.001	3	4
KIDNEY	TNP1 →	-0.259	-0.332	.003	<.001	3	4
OESOPHAGUS	KCNE5 →	+0.194	+0.377	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP7 by Maintenance of gastrointestinal epithelium activity — BREAST

Explore this box plot interactively →