Maintenance of gastrointestinal epithelium

Across TCGA cell cohorts, RNA activity of the Maintenance of gastrointestinal epithelium pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3A, CTNNB1, and BTBD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of gastrointestinal epithelium activity versus MEX3A in CNS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MEX3A →	+1.713	+0.217	.001	.002	3	4
BLOOD_Leukemia	CTNNB1 →	+0.712	+0.353	.001	.001	3	3
LUNG_NSCLC_LUAD	BTBD7 →	-0.510	-0.224	.008	.006	3	3
OESOPHAGUS	KLC1 →	-0.844	-0.495	.007	.003	3	3
LUNG_NSCLC_LUAD	SIN3B →	-0.773	-0.211	.002	.006	3	3
OESOPHAGUS	SEPTIN8 →	-0.917	-0.397	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030277 vs MEX3A — CNS

Explore this scatter interactively →