Apoptotic chromosome condensation

Across TCGA patient cohorts, RNA activity of the Apoptotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE2, ASF1B, and SGO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic chromosome condensation activity versus POLE2 in LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POLE2 →	+0.731	+0.269	<.001	<.001	3	8
UCEC	ASF1B →	+0.955	+0.314	.002	.001	3	7
UCEC	SGO1 →	+0.741	+0.275	<.001	<.001	3	7
GBM	SMC2 →	+0.489	+0.231	<.001	<.001	3	7
GBM	KNL1 →	+0.829	+0.275	<.001	<.001	3	7
BRCA	NEDD1 →	+0.527	+0.190	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030263 vs POLE2 — LUAD

Explore this scatter interactively →