Apoptotic chromosome condensation

Across TCGA cell cohorts, RNA activity of the Apoptotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPER1, KIF18B, and WDHD1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic chromosome condensation activity versus GPER1 in BLOOD_Lymphoma (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GPER1 →	-2.072	-0.140	<.001	<.001	3	15
URINARY_TRACT	KIF18B →	+1.464	+0.172	<.001	<.001	3	13
PANCREAS	WDHD1 →	+0.886	+0.159	<.001	<.001	3	12
BREAST	TOP2A →	+1.157	+0.183	<.001	<.001	3	12
PANCREAS	KIF23 →	+1.087	+0.144	<.001	.002	3	12
SOFT_TISSUE	NCAPD2 →	+1.112	+0.176	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030263 vs GPER1 — BLOOD_Lymphoma

Explore this scatter interactively →