Apoptotic chromosome condensation

Across TCGA cell cohorts, RNA activity of the Apoptotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGACT, CCDC159, and RAB3D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic chromosome condensation activity versus GGACT in OESOPHAGUS (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GGACT →	-2.136	-0.203	<.001	.001	3	5
BREAST	CCDC159 →	-1.499	-0.224	<.001	.002	2	6
BLOOD_Lymphoma	RAB3D →	-1.822	-0.156	<.001	.002	3	4
BLOOD_Lymphoma	GPR137C →	+0.564	+0.185	.009	.009	3	4
LUNG_NSCLC_LUSC	CPVL →	+3.773	+0.263	<.001	.002	3	4
LUNG_NSCLC_LUSC	SLC20A2 →	+1.049	+0.175	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030263 vs GGACT — OESOPHAGUS

Explore this scatter interactively →