Lipid glycosylation

pathway activity — cross-omics
GO:0030259Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Lipid glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GNT6, KIF1A, and PAN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADB3GNT6 →+2.079+1.193<.001<.00134
UCECKIF1A →+1.451+0.053.004.00234
LSCCPAN3 →-0.258-0.137<.001<.00134
COADRBM39 →-0.415-0.886<.001.00233
COADGRIN1 →+0.375+0.621<.001.00233
COADTTC39A-AS1 →+0.300+0.565.001.00633
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration