Lipid modification

Across TCGA patient cohorts, RNA activity of the Lipid modification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, STMN1, and RFC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid modification activity versus VRK1 in LSCC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	-0.835	-0.178	<.001	.004	3	5
LSCC	STMN1 →	-1.023	-0.197	<.001	<.001	3	5
LSCC	RFC4 →	-0.969	-0.177	<.001	.001	3	5
COAD	DLGAP5 →	-0.756	-0.207	.003	<.001	3	5
BRCA	FEN1 →	-0.481	-0.172	.005	<.001	3	5
COAD	MRPL11 →	-0.451	-0.124	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030258 vs VRK1 — LSCC

Explore this scatter interactively →