Growth hormone secretion

Across TCGA cell cohorts, RNA activity of the Growth hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNPK, MRPS22, and C1QL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone secretion activity versus LNPK in STOMACH (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LNPK →	-1.136	-0.367	.002	.003	3	3
BREAST	MRPS22 →	-0.862	-0.345	.001	.009	3	3
OVARY	C1QL1 →	-3.444	-0.321	<.001	<.001	3	3
STOMACH	SPC24 →	-1.782	-0.322	.004	.001	3	3
SKIN	TNPO1 →	-0.913	-0.469	.001	<.001	3	3
LARGE_INTESTINE	ANO7 →	-0.913	-0.293	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030252 vs LNPK — STOMACH

Explore this scatter interactively →