Skeletal muscle thin filament assembly

Across TCGA patient cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH7B, PROX1, and TNFSF10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle thin filament assembly activity versus MYH7B in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYH7B →	+1.340	+0.689	.006	.001	3	4
GBM	PROX1 →	+0.822	+0.872	<.001	<.001	3	4
CCRCC	TNFSF10 →	-0.666	-0.330	.004	<.001	3	3
CCRCC	PMEPA1 →	+0.596	+0.198	<.001	.009	3	3
CCRCC	IDH3A →	-0.287	-0.325	.004	.007	3	3
COAD	TMEM89 →	+0.589	+0.573	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030240 vs MYH7B — UCEC

Explore this scatter interactively →