Skeletal muscle thin filament assembly

Across TCGA cell cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT57, CHMP4B, and MAGED4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT57 grouped by Skeletal muscle thin filament assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFT57 →	-2.253	-1.089	.001	.006	3	5
LIVER	CHMP4B →	-0.746	-1.598	.001	.004	3	4
SOFT_TISSUE	MAGED4B →	-3.420	-1.626	.004	.001	3	4
SKIN	STK38 →	-0.536	-0.712	<.001	.005	3	3
SKIN	MSL1 →	-0.355	-0.652	.007	.009	2	4
SOFT_TISSUE	PCGF2 →	-0.547	-1.240	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT57 by Skeletal muscle thin filament assembly activity — LIVER

Explore this box plot interactively →