Skeletal muscle thin filament assembly

Across TCGA cell cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1B, ADGRD1, and NQO2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle thin filament assembly activity versus CDKN1B in LARGE_INTESTINE (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDKN1B →	-1.629	-1.458	.001	.006	3	1
LARGE_INTESTINE	ADGRD1 →	-0.930	-1.652	<.001	<.001	3	1
LARGE_INTESTINE	NQO2 →	-1.649	-1.180	.008	.005	3	1
LARGE_INTESTINE	RFXAP →	-0.991	-1.153	<.001	.007	3	1
LARGE_INTESTINE	FAM8A1 →	-0.799	-1.153	.007	.007	3	1
LARGE_INTESTINE	FRAS1 →	+2.786	+1.846	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030240 vs CDKN1B — LARGE_INTESTINE

Explore this scatter interactively →