Eosinophil differentiation

Across TCGA cell cohorts, RNA activity of the Eosinophil differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC7, SORL1, and HNRNPR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC7 grouped by Eosinophil differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANAPC7 →	+0.625	+1.471	.006	<.001	3	4
SKIN	SORL1 →	-1.331	-0.854	.002	<.001	3	4
STOMACH	HNRNPR →	+0.426	+1.003	.007	.003	2	4
STOMACH	DLG4 →	+1.537	+1.217	.003	.001	3	3
LARGE_INTESTINE	WRAP53 →	+0.665	+1.068	<.001	<.001	3	3
STOMACH	SLC9B2 →	+1.111	+1.132	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC7 by Eosinophil differentiation activity — STOMACH

Explore this box plot interactively →