Eosinophil differentiation

Across TCGA cell cohorts, RNA activity of the Eosinophil differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNA10, ATP6AP2, and ACTR6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNA10 grouped by Eosinophil differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KCNA10 →	+0.160	+0.711	<.001	.003	3	4
SKIN	ATP6AP2 →	-0.136	-0.928	.009	.005	2	4
SKIN	ACTR6 →	+0.154	+0.695	.002	.003	3	3
LUNG_NSCLC_LUAD	PRDX6 →	-0.207	-1.095	.001	<.001	2	4
LUNG_NSCLC_LUAD	PCDHGB2 →	+0.145	+0.769	<.001	<.001	3	3
BLOOD_Leukemia	SLC10A5 →	+0.207	+0.313	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNA10 by Eosinophil differentiation activity — CNS

Explore this box plot interactively →