Eosinophil differentiation

Across TCGA cell cohorts, RNA activity of the Eosinophil differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAGR1, SLC9A7, and HOXA9, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eosinophil differentiation activity versus PAGR1 in BLOOD_Leukemia (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAGR1 →	-0.739	-1.845	.009	<.001	3	1
BLOOD_Leukemia	SLC9A7 →	+2.370	+2.133	.002	.005	3	1
BLOOD_Leukemia	HOXA9 →	+4.770	+2.108	<.001	.007	3	1
BLOOD_Leukemia	ACOT8 →	-0.625	-1.845	.002	<.001	3	1
BLOOD_Leukemia	ASF1B →	-1.554	-2.133	.005	.005	3	1
BLOOD_Leukemia	MICU1 →	-1.395	-2.133	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030222 vs PAGR1 — BLOOD_Leukemia

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