Keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD5, KRT7, and MALL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte differentiation activity versus SMAD5 in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMAD5 →	-0.837	-0.179	.003	.008	3	2
BRCA	KRT7 →	+3.310	+0.236	.005	.003	3	2
BRCA	MALL →	+1.593	+0.235	.002	.003	3	2
BRCA	N6AMT1 →	-0.999	-0.240	<.001	<.001	3	2
BRCA	ALS2CL →	+1.468	+0.238	<.001	.004	3	2
BRCA	C2orf69 →	-0.946	-0.238	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030216 vs SMAD5 — BRCA

Explore this scatter interactively →