Keratinocyte differentiation

Across TCGA cell cohorts, RNA activity of the Keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRXL2A, C11orf52, and SLC10A5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRXL2A grouped by Keratinocyte differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRXL2A →	+2.108	+0.923	.002	<.001	3	7
LUNG_NSCLC_LUAD	C11orf52 →	+2.027	+1.305	<.001	<.001	3	5
LUNG_NSCLC_LUAD	SLC10A5 →	+0.410	+0.925	.006	<.001	3	5
LUNG_NSCLC_LUSC	LLGL2 →	+1.951	+1.570	.008	<.001	3	5
LUNG_NSCLC_LUSC	LRP1 →	-2.214	-1.293	<.001	<.001	3	5
STOMACH	ZNFX1 →	-1.142	-1.143	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRXL2A by Keratinocyte differentiation activity — BREAST

Explore this box plot interactively →