Heparin metabolic process

Across TCGA patient cohorts, RNA activity of the Heparin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGM5, ENG, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin metabolic process activity versus PGM5 in COAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PGM5 →	+0.743	+0.029	<.001	<.001	3	9
CCRCC	ENG →	+0.406	+0.051	.001	<.001	3	8
COAD	RSU1 →	+0.405	+0.023	<.001	<.001	3	8
LSCC	SH3D19 →	+0.371	+0.081	<.001	<.001	3	8
LSCC	TNS2_S120 →	+0.675	+0.075	<.001	<.001	3	8
LSCC	GEM_S23 →	+0.961	+0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030202 vs PGM5 — COAD

Explore this scatter interactively →