Heparin metabolic process

Across TCGA patient cohorts, RNA activity of the Heparin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC160, KRT8P40, and SNAP25-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin metabolic process activity versus CCDC160 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCDC160 →	+1.003	+0.749	.003	.002	3	3
LUAD	KRT8P40 →	+0.242	+0.591	<.001	.003	3	3
CCRCC	SNAP25-AS1 →	+0.295	+0.553	.001	.001	3	3
BRCA	SMARCA1 →	+0.820	+0.409	<.001	<.001	3	3
PDAC	KANSL1 →	-0.357	-0.885	.001	<.001	3	2
PDAC	ATP6V1F →	+0.198	+0.524	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030202 vs CCDC160 — LUAD

Explore this scatter interactively →