Heparin metabolic process

Across TCGA cell cohorts, RNA activity of the Heparin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD63, THADA, and CDC42SE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD63 grouped by Heparin metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD63 →	-1.284	-1.304	<.001	<.001	3	4
SOFT_TISSUE	THADA →	-1.066	-1.518	.002	.002	3	4
BREAST	CDC42SE1 →	-1.224	-0.884	<.001	.003	3	4
BLOOD_Myeloma	PLOD3 →	-0.673	-1.416	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	BIRC2 →	+2.099	+0.488	.007	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CCDC82 →	+1.976	+0.503	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD63 by Heparin metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →