Heparin metabolic process

Across TCGA cell cohorts, RNA activity of the Heparin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLK8, CEP57L1, and ANKRD39, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin metabolic process activity versus KLK8 in OVARY (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KLK8 →	-4.621	-1.376	<.001	<.001	3	7
LARGE_INTESTINE	CEP57L1 →	+0.937	+1.127	.004	.005	2	8
STOMACH	ANKRD39 →	+1.031	+1.092	<.001	<.001	3	7
PANCREAS	KLK10 →	-4.796	-1.462	<.001	<.001	3	6
URINARY_TRACT	LAMA3 →	-4.814	-1.948	.001	<.001	3	6
PANCREAS	RPL3 →	+0.742	+1.808	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030202 vs KLK8 — OVARY

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