Heparan sulfate proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Heparan sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBP, LZIC, and ADI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EBP grouped by Heparan sulfate proteoglycan metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EBP →	+1.478	+1.644	.002	.001	3	5
LIVER	LZIC →	+0.618	+1.633	.002	<.001	3	4
LIVER	ADI1 →	+0.833	+1.328	.003	.003	2	5
LUNG_NSCLC_LUSC	HAGHL →	-1.705	-1.448	<.001	<.001	3	4
BLOOD_Myeloma	NAGPA →	+1.616	+1.680	<.001	<.001	3	4
BLOOD_Myeloma	SPNS1 →	+1.459	+1.723	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EBP by Heparan sulfate proteoglycan metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →