Heparan sulfate proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Heparan sulfate proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA3, GSR, and KLK8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparan sulfate proteoglycan metabolic process activity versus LAMA3 in LARGE_INTESTINE (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LAMA3 →	-1.907	-0.865	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	GSR →	+1.528	+1.310	.001	.001	3	6
BREAST	KLK8 →	-2.250	-0.584	.003	.003	3	5
LARGE_INTESTINE	LAMC2 →	-2.470	-0.654	<.001	.002	3	5
LUNG_NSCLC_LUAD	GPR87 →	-2.066	-0.381	.002	.005	3	4
LIVER	ALDH2 →	+2.128	+0.377	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030201 vs LAMA3 — LARGE_INTESTINE

Explore this scatter interactively →