Nitric oxide transport

Across TCGA patient cohorts, RNA activity of the Nitric oxide transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RHAG, SLC4A1, and SPTB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nitric oxide transport activity versus RHAG in BRCA (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RHAG →	+1.945	+0.244	<.001	.003	3	9
CCRCC	SLC4A1 →	+1.182	+0.120	<.001	<.001	3	9
CCRCC	SPTB →	+1.060	+0.085	<.001	<.001	3	9
CCRCC	EPB42 →	+1.012	+0.139	<.001	<.001	3	9
GBM	ANK1 →	+1.021	+0.184	<.001	<.001	3	9
CCRCC	GYPA →	+1.126	+0.086	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030185 vs RHAG — BRCA

Explore this scatter interactively →