Nitric oxide transport

Across TCGA pan-cancer cohorts, RNA activity of the Nitric oxide transport pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and KICH, show the opposite pattern, with lower activity in tumor tissue.

COAD, KICH, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	III,IV	−0.197	<.001	12	view →
KICH	Male	III,IV	−0.227	<.001	10	view →
LUSC	Female	II,III,IV	−0.320	<.001	9	view →
LUAD	Male	II,III,IV	−0.180	<.001	9	view →
KIRP	Male	All	−0.100	<.001	9	view →
BRCA	All	III,IV	−0.221	<.001	8	view →
THCA	All	All	−0.061	<.001	7	view →
UCEC	All	All	−0.108	.001	6	view →
LIHC	Male	All	−0.069	<.001	6	view →
BLCA	Male	III,IV	−0.118	.006	4	view →
STAD	All	II,III,IV	−0.079	.019	4	view →
HNSC	All	All	−0.060	.010	3	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0030185–COAD

Open the COAD breakdown →