Nitric oxide transport

Across TCGA cell cohorts, RNA activity of the Nitric oxide transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF174, CD81, and SCNN1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF174 grouped by Nitric oxide transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF174 →	+0.521	+1.065	<.001	.001	3	4
LARGE_INTESTINE	CD81 →	+0.970	+1.056	<.001	<.001	3	4
LARGE_INTESTINE	SCNN1D →	+0.728	+0.878	.003	.004	3	4
LUNG_NSCLC_LUSC	HYI →	+2.349	+1.620	.003	.006	3	4
OESOPHAGUS	RABGGTB →	+0.771	+1.187	.001	.005	3	4
SKIN	SUCO →	+0.684	+1.195	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF174 by Nitric oxide transport activity — LARGE_INTESTINE

Explore this box plot interactively →