Nitric oxide transport

Across TCGA cell cohorts, RNA activity of the Nitric oxide transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, PDLIM1, and THBS1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nitric oxide transport activity versus EDN1 in KIDNEY (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EDN1 →	+3.860	+1.842	<.001	<.001	3	15
BONE	PDLIM1 →	+2.888	+0.947	<.001	<.001	3	8
KIDNEY	THBS1 →	+2.881	+1.579	<.001	<.001	3	7
OESOPHAGUS	PCSK4 →	-1.436	-1.109	<.001	.009	3	7
SKIN	LONRF1 →	-0.828	-0.712	.005	<.001	3	7
BLOOD_Leukemia	WAS →	-0.902	-0.933	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030185 vs EDN1 — KIDNEY

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