B cell differentiation

Across TCGA patient cohorts, RNA activity of the B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00426, CXCL13, and HSPBAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell differentiation activity versus LINC00426 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00426 →	+1.051	+0.245	.003	.009	3	4
UCEC	CXCL13 →	+2.551	+0.269	.009	.004	3	4
HNSC	HSPBAP1 →	+0.786	+0.134	.001	.001	3	4
OV	DNM1 →	+1.142	+0.506	.004	.005	3	3
OV	SYT15 →	+0.222	+0.411	.007	.005	2	4
OV	RPS3AP27 →	+0.119	+0.410	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030183 vs LINC00426 — UCEC

Explore this scatter interactively →