B cell differentiation

Across TCGA cell cohorts, RNA activity of the B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM117B, WASF1, and ACAA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell differentiation activity versus FAM117B in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM117B →	+1.085	+0.241	.005	<.001	3	6
BLOOD_Lymphoma	WASF1 →	+2.638	+0.293	<.001	<.001	3	6
SOFT_TISSUE	ACAA2 →	+1.589	+0.186	.002	.005	3	6
BLOOD_Lymphoma	IL12A →	-1.635	-0.226	<.001	<.001	3	5
BLOOD_Lymphoma	GNAZ →	+1.816	+0.219	<.001	.006	3	5
BLOOD_Lymphoma	PDXP →	+1.304	+0.356	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030183 vs FAM117B — BONE

Explore this scatter interactively →