Negative regulation of Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10A, UQCRC2, and MRPL24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Wnt signaling pathway activity versus TRMT10A in OESOPHAGUS (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRMT10A →	-0.826	-0.323	.004	.002	3	6
UPPER_AERODIGESTIVE_TRACT	UQCRC2 →	-0.959	-0.229	.008	.002	3	6
BREAST	MRPL24 →	-0.888	-0.179	<.001	.005	3	5
BLOOD_Leukemia	RPL9 →	-0.445	-0.156	.007	.008	3	5
LARGE_INTESTINE	EIF4B →	-0.768	-0.230	<.001	<.001	3	5
PANCREAS	STX12 →	+0.742	+0.241	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030178 vs TRMT10A — OESOPHAGUS

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