Regulation of DNA-templated DNA replication initiation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated DNA replication initiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and H1-10_S31, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated DNA replication initiation activity versus SMC2 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.756	+0.122	<.001	<.001	3	10
GBM	SMC4 →	+0.711	+0.121	<.001	<.001	3	10
GBM	H1-10_S31 →	+1.349	+0.129	<.001	<.001	3	10
GBM	MCM5 →	+0.880	+0.129	<.001	<.001	3	10
GBM	LIG1 →	+0.514	+0.106	<.001	<.001	3	10
BRCA	TFDP1_S23 →	+0.868	+0.065	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030174 vs SMC2 — GBM

Explore this scatter interactively →