Regulation of DNA-templated DNA replication initiation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51AP1, FBXO5, and TTK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated DNA replication initiation activity versus RAD51AP1 in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAD51AP1 →	+0.979	+0.312	<.001	<.001	3	8
GBM	FBXO5 →	+0.940	+0.303	<.001	<.001	3	8
BRCA	TTK →	+1.048	+0.412	<.001	<.001	3	8
GBM	HELLS →	+0.718	+0.231	<.001	<.001	3	8
BRCA	HJURP →	+1.017	+0.460	<.001	<.001	3	8
BRCA	TOP2A →	+1.240	+0.648	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030174 vs RAD51AP1 — GBM

Explore this scatter interactively →