Sphingolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28_S697, RIN3, and ADAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid catabolic process activity versus TRIM28_S697 in PDAC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRIM28_S697 →	-0.440	-0.029	.002	.001	3	7
GBM	RIN3 →	+0.339	+0.080	<.001	<.001	3	6
GBM	ADAP2 →	+0.414	+0.072	<.001	<.001	3	6
GBM	DHX9 →	-0.340	-0.102	<.001	<.001	3	6
GBM	FAM114A1 →	+0.510	+0.088	<.001	<.001	3	6
GBM	GATAD2B →	-0.443	-0.099	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030149 vs TRIM28_S697 — PDAC

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