Sphingolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBK, SAFB, and CDC5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid catabolic process activity versus PBK in LSCC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PBK →	-0.785	-0.261	<.001	<.001	3	5
LSCC	SAFB →	-0.280	-0.201	<.001	<.001	3	4
GBM	CDC5L →	-0.259	-0.200	<.001	<.001	3	4
LSCC	PRKCD_S304 →	+0.699	+0.280	<.001	<.001	3	4
GBM	PRKCD_S664 →	+1.526	+0.215	<.001	<.001	3	4
LSCC	MCM2_S27 →	-0.822	-0.217	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030149 vs PBK — LSCC

Explore this scatter interactively →