Sphingolipid catabolic process

Across TCGA cell cohorts, RNA activity of the Sphingolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPHS2, ULK4, and ZNF593, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPHS2 grouped by Sphingolipid catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SEPHS2 →	-0.811	-1.055	.002	.001	3	6
BLOOD_Myeloma	ULK4 →	-1.225	-1.431	.006	.003	3	4
LUNG_SCLC	ZNF593 →	-0.733	-1.231	.004	<.001	3	4
LUNG_SCLC	FAM193B →	+0.699	+1.080	.004	.008	2	5
KIDNEY	SLC7A6OS →	-0.636	-1.450	<.001	.001	3	4
KIDNEY	ACAA1 →	-0.787	-1.314	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPHS2 by Sphingolipid catabolic process activity — LUNG_SCLC

Explore this box plot interactively →