Sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP35, CFAP53, and TOR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid biosynthetic process activity versus NUP35 in OVARY (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NUP35 →	-0.713	-0.232	.002	.006	3	5
OVARY	CFAP53 →	+0.554	+0.256	<.001	<.001	3	4
BONE	TOR1A →	+0.814	+0.366	.004	<.001	3	4
OVARY	POLR2D →	-0.572	-0.203	.001	.008	2	5
OVARY	VPS9D1 →	+1.333	+0.345	<.001	.002	3	4
CNS	UNC93B1 →	+0.999	+0.279	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030148 vs NUP35 — OVARY

Explore this scatter interactively →