Regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM5, ZSCAN18, and AHI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ICAM5 grouped by Regulation of endocytosis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ICAM5 →	-1.830	-0.165	.002	<.001	3	4
LUNG_SCLC	ZSCAN18 →	+2.311	+0.145	<.001	.002	3	4
SOFT_TISSUE	AHI1 →	-1.325	-0.204	.005	<.001	3	3
SOFT_TISSUE	ANKAR →	-0.840	-0.158	.009	.001	3	3
SOFT_TISSUE	CCDC125 →	-1.298	-0.197	.007	<.001	3	3
SOFT_TISSUE	MLXIPL →	-1.332	-0.169	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICAM5 by Regulation of endocytosis activity — LUNG_SCLC

Explore this box plot interactively →