Insulin processing

Across TCGA patient cohorts, RNA activity of the Insulin processing pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERO1B, AKAP12_S1331, and SPC24, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin processing activity versus ERO1B in LUAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ERO1B →	+0.706	+0.095	<.001	<.001	3	7
BRCA	AKAP12_S1331 →	+0.793	+0.072	<.001	<.001	3	6
OV	SPC24 →	-0.525	-0.068	<.001	.001	3	5
PDAC	SPTLC1 →	-0.184	-0.090	.001	<.001	3	5
UCEC	SYNPO2_S226 →	+0.698	+0.109	<.001	<.001	3	5
PDAC	TNS2_S941 →	+0.275	+0.084	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030070 vs ERO1B — LUAD

Explore this scatter interactively →