Maintenance of cell polarity

Across TCGA patient cohorts, RNA activity of the Maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPGDS, DYNLT3, and LINC01645, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell polarity activity versus HPGDS in CCRCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HPGDS →	+0.497	+0.561	<.001	<.001	3	3
CCRCC	DYNLT3 →	+0.250	+0.454	.007	.008	3	3
CCRCC	LINC01645 →	+0.299	+0.504	<.001	.001	3	3
LUAD	DIAPH2 →	+0.471	+0.852	.006	<.001	3	3
GBM	CAV1 →	+1.195	+0.284	.003	.004	3	3
LSCC	OR7E13P →	+0.448	+0.493	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030011 vs HPGDS — CCRCC

Explore this scatter interactively →