Intracellular monoatomic anion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAS4, PCBD2, and CCDC148, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular monoatomic anion homeostasis activity versus BCAS4 in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCAS4 →	+0.488	+0.435	.001	.002	3	4
BRCA	PCBD2 →	+0.464	+0.633	<.001	<.001	3	4
BRCA	CCDC148 →	+0.503	+0.718	<.001	<.001	3	4
BRCA	STK39 →	+1.111	+0.926	<.001	<.001	3	4
BRCA	FBP1 →	+1.001	+0.620	.002	.003	3	3
OV	HNRNPA1P64 →	-0.293	-0.275	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030002 vs BCAS4 — LUAD

Explore this scatter interactively →