Intracellular monoatomic anion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, STK39, and FASLG, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNK1 grouped by Intracellular monoatomic anion homeostasis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WNK1 →	-0.499	-0.314	.001	<.001	3	10
OVARY	STK39 →	-0.171	-0.577	.002	.002	2	6
CNS	FASLG →	-0.256	-0.891	.002	.002	3	5
CNS	TBXAS1 →	-0.138	-0.748	.002	.001	3	5
LUNG_SCLC	SLC12A5 →	-0.230	-1.451	.003	<.001	3	4
LUNG_SCLC	TPTE →	-0.235	-1.246	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNK1 by Intracellular monoatomic anion homeostasis activity — STOMACH

Explore this box plot interactively →