Intracellular monoatomic anion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER5, RPS4X, and TMEM9B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IER5 grouped by Intracellular monoatomic anion homeostasis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IER5 →	-0.925	-0.968	.009	.009	2	5
BREAST	RPS4X →	-0.646	-0.791	<.001	<.001	3	4
KIDNEY	TMEM9B →	-0.651	-1.440	<.001	<.001	3	4
SOFT_TISSUE	MT-ND2 →	-1.216	-1.235	<.001	<.001	3	4
SKIN	EDA2R →	-1.737	-0.769	<.001	<.001	3	3
SKIN	TWF1 →	-0.321	-0.700	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IER5 by Intracellular monoatomic anion homeostasis activity — KIDNEY

Explore this box plot interactively →